Tuesday, April 26, 2016

Gut feeling: bacteria in your gut might be affecting your mind

This is a frantic time for the stomach bug. The heat, lowered water levels and vacationing crowds bring a host of stomach infections with them. Many of you like me might have already suffered. After a few days of antibiotics and food restrictions we get better. We no longer give a thought to the bacteria in the gut, except with a sense of passing annoyance.

But these little guys in your stomach might be far more important than we think (or don’t think). If the hints scientists are getting turn out to be correct, gut bacteria (or microbiome, as they are called), might be having profound effect on the development of our brains and our mental well being.

In some interesting experiments on mice, researchers found clear links between microbiome and anxiety. They delivered some baby mice through caesarean procedure. Such mice had a different microbiome from the baby mice born though vaginal delivery, who acquired the vaginal bacteria of their mothers. The researchers found that the caesarean born mice had higher anxiety levels than the normally born mice. It’s too early to link this observation to human beings, but this just points out the kind of discoveries we might make.

Some studies are happening on human beings. After the 2000 flooding of many Canadian regions, more than 2000 people were affected by gastrointestinal problems, such as irritable bowl syndrome (IBS). Researchers studying the affected people found a clear correlation between psychological disorders such as depression and anxiety and IBS. Scientists are working on the question of whether the destruction of gut bacteria due to infection caused the mental disorders. Links of gut bacteria with disorders like autism have already been seen.

The obvious question is: how can bacteria in stomach affect the brain? Microbes in blood cannot enter the brain cells due to what is called as the blood-brain barrier. Some microbes like the Rabies virus break this barrier and enter neurons, playing havoc with us such as making us afraid of water among other things.

But gut bacteria mostly do not take such drastic steps. They have other powerful weapons at their disposal. The waste products of many gut bacteria contain neurotransmitters, the chemicals that our brain cells use to talk to each other. An example is the neurotransmitter Serotonin. Scientists found that levels of Serotonin in blood change significantly when microbiome is changed. This might be affecting our brains.

Gut bacteria might also be have other complex effects on the development of baby brains. As an example, they might be affecting a process called Myelination, a kind of covering up of neurons. The chemicals produced by these bacteria might be triggering growth of neurons in particular places in the young brains.

Finding these links is important because then we can use them for treatment. An interesting research is going on at the McMuster University, Ontario in Canada. The Office of Naval Research has funded a research project to find a treatment that will help soldiers deal with stress better. The fighters have to face several high-stress situations in their work. It is possible that supplementing them with proper gut bacteria might improve their stress handling capability. I think we might all benefit from such a discovery!

Naturally, the pharmaceutical industry sees a big opportunity in this research. Since 2008, more than 500 million dollars have been spent in finding microbiome based treatment for mental disorders. We haven’t seen much success yet, but some good breakthroughs may be just round the corner. Of course, ‘Probiotic’ yogurt and probiotic supplement tablets are already here. But though harmless, they haven’t been found effective in anything.

This might change very soon as we understand the links between gut bacteria and brain (called the microbiome-gut-brain axis) better. I would love to report the progress as it is published.